This inhibition occurs at both the spinal cord level and within the brain, where pain perception is processed

When opioids bind to the mu receptors, for example, they primarily induce analgesic effects by inhibiting the release of neurotransmitters involved in pain transmission. This inhibition occurs at both the spinal cord level and within the brain, where pain perception is processed. Additionally, activation of mu receptors is associated with feelings of euphoria, which can contribute to the potential for misuse and addiction. On the other hand, delta receptors are believed to play a role in emotional regulation and may enhance the analgesic effects when activated alongside mu receptors. Kappa receptors, while less involved in pain relief, can produce dysphoria and have been linked to a more complex interaction with mood and stress responses.